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Published 15:42 29 Aug 2019 BST
"We are backsliding, we are on the wrong track," said O'Brien.
"This is the alarm bell that is ringing around the world: being able to achieve high national coverage is not enough, it has to be achieved in every community, and every family for every child.
"We have a worrying trend that all regions are experiencing an increase in measles except for the region of the Americas, which has seen a small decline."
O'Brien asked community leaders to combat misinformation and scaremongers and to instead provide "accurate, valid, scientifically credible information."
She also said that WHO sees widely circulated myths about vaccines to be a "threat" to public safety.
Almost 365,000 cases of measles have been reported globally this year, with an estimated 109,000 deaths reported in 2017.
Measles is most common among children aged between one and four years old, although anyone who has not been vaccinated against measles can catch it.
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