It's going to shake up Grey Sloan.

Grey's Anatomy's fourteenth season kicked off this week, and things in Grey Sloan Memorial Hospital won't ever be quite the same. Major spoilers for season 14 of Grey's Anatomy lie ahead. Again, if you're not all caught up on the recent series of Grey's Anatomy, proceed at your own risk. Grey’s Anatomy returned to the small screen this week with a lighter, happier and overall funnier premiere - until the last few moments. The two-hour opening episode threw a serious curveball for one of the series’ long-running characters…and it’s an absolute heartbreaker. After clashing with everyone around her for the premiere, Dr Amelia Shepherd found out in the closing minutes of the episode that she had a giant brain tumour. The neurosurgeon had been acting erratic for a few episodes now, but her fellow doctors at Grey Sloan seemed to assume it had something to do with lingering PTSD from one of the (many) devastating things that had previously happened in her life. And her diagnosis begins to call into question some of the decisions she’s made over the years - even possibly going back to her time on Private Practice, where she was known for making impulsive choices and had trouble with addiction. Kevin McKidd, who plays Amelia’s husband Dr Owen Hunt, told Entertainment Weekly:

“She hasn’t known for many, many years, and this tumour has been growing for a long, long, long time and has been affecting all her choices and all of her actions and nobody knew it, least of all her. “So it’s a tough one for Owen because he’s left with dealing with this person who, going forward, if they manage to remove the tumour, could potentially have a very different personality to the one that he married. “She has a lot of questions about, ‘Who actually will I be when this thing is taken away from me?’ So it’s going to impact everything.”

The actor went on to say that even though Amelia tries to keep her diagnosis a secret, it doesn’t take long for her husband to find out - and despite their recent tension, “he definitely steps up in the role he should do”. He added:

“He doesn’t know that the tumour exists. “It doesn’t take too long for him to find out, and he steps up as a husband should. “Even if Amelia said certain things to him, and even if he’s obviously very conflicted and very much looking at the possibility that this marriage might not work, and they’re on different pages, he definitely steps up in the role as he should do.”