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Published 12:44 19 Apr 2022 BST
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A number of cases of this new variant have been reported in Northern Ireland.
O'Neill said that the one good take from this is that the immune system is still holding up in preventing people from becoming seriously ill from the virus.
"It's like a deck of cards and it keeps getting reshuffled," he said.
"You know an immune system can recognise the same cards, basically. So far the worry would be a new deck of cards might emerge, or a different kind of suit of cards ... might emerge, and then we might be in more trouble, but for the moment as I say it's the same deck of cards being reshuffled basically."
He also noted that antiviral medications will work on the variants, but the "holy grail" will be access to pan-virus medication which will not only work against all future variants but will stop the virus from transmitting.
He said that next-gen vaccines will be the next tool in fighting this disease and to combat it in the meantime, we must all still continue to wear masks and use antigen tests.
Antigen tests are able to detect newer variants and O'Neill said there will be less infection to deal with over the summer.
"But come September, October there's bound to be a surge because we're back indoors again. I'm keeping my fingers crossed that these next-gen vaccines will be rolled out as soon as we possibly can, otherwise there could be problems with these new variants that keep emerging," he warned.Signs Charleen Murphy could be heading into the Love Island villa labi e
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