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Published 17:08 18 May 2015 BST
Updated 13:28 11 Jun 2015 BST
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Dear #JIBCON and #AHBL6. I am in desperate and urgent need of my family. I am so sorry to tell you this but I must head home.
— Jared Padalecki (@jarpad) May 16, 2015
I need all of the love I can get right now. Please please give me a few seconds of your time and write me. #AlwaysKeepFighting — Jared Padalecki (@jarpad) May 16, 2015
His manager later released a statement confirming that Padalecki was "very upset" at having to cancel his appearance at the events in Rome and Australia but had "pushed himself to his limits" and was suffering from exhaustion.
"He's doing better already and is excited about shooting Supernatural Season 11 this July. For now he's taking a break, but is so appreciative of his fans, and sees and feels their love and support."
Co-star Jensen Ackles has also spoke out in support of the actor, saying "He's a big guy with a big heart, and sometimes he just doesn't know when to stop giving himself".
"And he gives himself a lot to what he does, he gives himself a lot to you guys, and he gives himself a lot to his family, and his friends, and his work, and his job. Sometimes you just need to get home and rest with your family. That's what he's doing."

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