The radio presenter confirmed the news on Twitter on Friday morning.
Louise McSharry has announced her decision to leave RTE 2FM after 11 years, saying that it is time for her to "move on".
Taking to Twitter, the presenter wrote:
"After eleven years on RTE2FM, the time has come for me to move on. I’d like to thank RTE for the time I spent as part of the organisation, and particularly for the support it offered me around my illness in 2014 and 2015.
"I relished having the opportunity to play and support emerging Irish artists on the new music show I presented for five years, and look forward to seeing 2fm’s continued support of Irish music from the outside.
https://twitter.com/louisemcsharry/status/1454010260516216832
"I am especially grateful for the opportunity over the last two years to create a talk show I’m really proud of.
"It was an immense privilege to be part of people’s lives during such a difficult time for us as a society, and I will never forget it.
“Thank you so much to all the listeners for your continued support, you have made my career so far. I’m nowhere near finished yet, so hope you’ll all join me in my next chapter."
Louise presents her own show on Saturday and Sunday mornings from 9-11am.
She previously took time off from RTE in 2014 and 2015, after being diagnosed with cancer, but made a full recovery.
Many took to the comments to support Louise and offer their well wishes.
"You’re a top pro and a wonderful person. Congratulations on a great innings and excited to see the next steps!" wrote Virgin Media journalist Richard Chambers.
"Wow huge news! I can’t wait to see what you do next. So talented in so many ways and being on your show was always such a pleasure. Best of luck Louise!" another person added.
"You are certainly a highlight on the media landscape; looking forward to your next endeavour," a third replied.
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