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Published 15:43 22 Sept 2016 BST
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In the five-minute clip, Galifianakis asks Clinton if she's excited to be the first "girl president," before reminding her that "for a younger generation you will also become their first white president, so that's pretty cool, too."
He also goads her by asking "as Secretary, how many words per minute could you type?"
Fair play to Hillary, she peppers her replies with sass alongside policy, and gets a few digs in at Trump too.
You can watch the full clip below, or on Funny Or Die's site.
https://twitter.com/funnyordie/status/778957045357772800News